The US natural gas pipeline industry is constantly evolving amid basin development, changes in regulations and shifting demand dynamics. The latest regulatory reforms under US President Donald Trump’s administration have the potential to usher in a new era by spurring pipeline project development and fuelling broader US gas market expansion. In addition to regulatory support, commercial momentum for funding new pipeline projects is also undergoing a fundamental change. In this insight, we analyze how these shifting funding mechanisms, regulatory changes and massive infrastructure investment will impact stakeholders in every part of the natural gas value chain, creating both opportunities and challenges.